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Colchicine is a medication used to treat painful attacks of gout. Gout causes inflammation of the joints, particularly of the big toe. Colchicine is taken during a gout attack to reduce pain, inflammation and swelling.

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    • Colchicine is an anti-inflammatory medication taken during an attack of gout 
    • Colchicine should only be taken until the pain eases, or a maximum of 12 tablets per attack of gout
    • Colchicine is sometimes known by its brand names Colcrys or Mitigare
    • Colchicine can occasionally cause nausea (feeling sick) or diarrhoea
    • You must not drink grapefruit juice or eat grapefruit whilst taking colchicine
    • It is important to read the patient leaflet for a full list of side effects and cautions.

    Colchicine is taken during an attack of gout. Gout is an inflammatory condition that causes a build-up of uric acid crystals in the joints. The joint most commonly affected by gout is the big toe. The crystals cause irritation that is extremely painful, and also cause swelling and inflammation.

    Colchicine is an alternative to taking anti-inflammatory medications such as ibuprofen. Colchicine reduces the number of white blood cells that travel to the inflamed joint, helping to minimise the swelling and pain associated with gout.

    Colchicine is a tablet that is swallowed with some water. Colchicine can be taken with or without food.

    1mg of colchicine (two tablets) is usually taken as the first dose, followed by 500mcg (1 tablet) an hour later. No more tablets should be taken for 12 hours. 

    12 hours after the initial doses, one 500mcg tablet can be taken every 8 hours until symptoms settle.

    No more than 12 tablets (6mg) should be taken during a single attack of gout.

    Like all medications, colchicine can have some side effects. The most common side effects include:

    • Nausea or vomiting (feeling sick or being sick)
    • Tummy (abdominal) pain
    • Diarrhoea.

    If any of these side effects occur, stop taking colchicine and let the symptoms settle. If the side effects persist, you should speak to your doctor for advice.

    If you have a severe allergic reaction (anaphylaxis) including breathlessness, lip or tongue swelling, call 999 immediately.

    Colchicine may not be suitable for everyone. You should tell your doctor if you:

    • Have heart disease
    • Have liver or kidney disease
    • Have digestive problems
    • Have a blood disorder
    • Have ever had an allergic reaction to colchicine or any other medication
    • Are pregnant, trying to conceive, or breastfeeding.

    Some medications can interact with colchicine. You may be advised that colchicine will not suit you if you already take:

    • Antibiotics
    • Heart or blood pressure medications
    • Medications for HIV
    • Disulfiram (for alcohol abuse). 

    Grapefruit juice can increase the amount of colchicine in your blood. You should therefore avoid drinking grapefruit juice or eating grapefruit whilst taking colchicine.

    Because colchicine may not suit everyone, we will complete a Consultation with you including a health questionnaire. This will ensure that the medication will be suitable for you.

    A qualified prescriber will review your current medications, including any herbal remedies or supplements, to ensure that colchicine will not interact with them. 

    Once prescribed, colchicine will be ordered on your behalf via electronic prescription, allowing you to pick the medication up at your convenience.

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