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Sereflo is the brand name for an inhaler that contains the steroid fluticasone and a bronchodilator called salmeterol. It is prescribed for adults with asthma. Sereflo is a preventer inhaler that should be used regularly to prevent flare ups of asthma.

  • Provides day-to-day relief
  • Prevents attacks of breathlessness
  • Effectively relieves symptoms
  • Genuine medication
  • Shipped from EU Pharmacies
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  • Sereflo is a preventer inhaler used to keep the symptoms of asthma under control
  • Sereflo contains a steroid called fluticasone and a bronchodilator called salmeterol
  • Sereflo reduces the inflammation within the airways making it easier to breathe, as well as reducing asthma symptoms including wheeze and cough
  • You will likely also require a reliever inhaler to be taken in case of an asthma attack (exacerbation of asthma)
  • It is important to read the patient leaflet for a full list of side effects and cautions.

Sereflo is an inhaler that contains two different drugs. The first is the steroid fluticasone. Fluticasone helps to reduce the swelling within the airways. It does this by dampening down the actions of inflammatory cells in the airways, including mast cells and white blood cells.

Once the swelling is minimised, it is easier to draw air into the lungs via the airways. This makes your breathing feel easier and helps to reduce wheezing.

Sereflo also contains the long acting bronchodilator salmeterol. It relaxes the muscles around the airways, helping to open the passageways to make it easier to breathe.

Some people feel an improvement soon after taking their inhaler. However, it can take up to two weeks before you notice the full benefit of taking Sereflo inhaler. At this point, it is important to continue using your inhaler every day as prescribed. Stopping your inhaler is likely to lead to your symptoms of asthma recurring.


You may also need a “reliever” inhaler in case of a sudden flare up of symptoms including breathlessness, wheezing, coughing, or an asthma attack.

Sereflo inhaler should be taken every day to keep your symptoms under control. It is important to read the manufacturer’s instructions to ensure you get the full dose of the medications.

The following may help you understand how to take your inhaler.

  1. Sit or stand up straight to take your inhaler.
  2. Check the dose counter to be sure that the inhaler isn’t empty.
  3. Remove the cover and check there is nothing inside the mouthpiece.
  4. Shake the inhaler well.
  5. Breathe out away from the inhaler.
  6. Put the mouthpiece into your mouth and close your lips around it to form a good seal. Do not bite the inhaler.
  7. Push the top of the canister down firmly and breathe in quickly and deeply. This will help to draw the medication into the lungs.
  8. Take your finger off the canister and remove the inhaler from your mouth, then keep your mouth closed.
  9. Hold your breath for 10 seconds, or for as long as is comfortable.
  10. Breathe out slowly.
  11. If you are prescribed a second dose, repeat steps 4 to 10.
  12. Replace the cap of the inhaler.

Some people find it easier to take their Sereflo inhaler with a spacer device. Speak to your doctor if you think you might benefit from using a spacer.

Sereflo inhaler is only suitable for adults.

Sereflo inhaler is available in two strengths:

  • 25/125 contains 25 micrograms of salmeterol and 125 micrograms of fluticasone per spray.
  • 25/250 contains 25 micrograms of salmeterol and 250 micrograms of fluticasone per spray.

Your doctor will prescribe the correct dose for you. Whether you take the lower or higher strength inhaler, the most commonly prescribed dosage is two puffs, taken twice daily.

Like all medications, Sereflo can have some side effects. The most common side effects include:

  • Headache
  • Inflammation or infection of the nose or throat
  • Irritation of the throat
  • Hoarse voice
  • Sinusitis
  • Skin bruising more easily
  • Muscle cramps
  • Aches and pains
  • Candida of the mouth (a fungal infection in the mouth)
  • Chest infections
  • Low potassium level on blood testing.

Some side effects are likely to settle down, but if they persist or become troublesome you should speak to your doctor for further advice. If you think you have an infection, contact your doctor as antimicrobial treatment may be required.

The risk of developing a fungal infection in the mouth can be reduced by rinsing your mouth with water after taking the inhaler. 

More serious side effects are rare. They are more likely if you have been taking Sereflo or another steroid inhaler or tablet for a long time. The side effects include:

  • Signs of an infection including high temperature, cough with phlegm or mucus, pain on passing urine (peeing), or mouth sores
  • A round puffy face known as ‘moon face’ – this can be a sign of Cushing’s Syndrome
  • Diarrhoea and vomiting, loss of appetite, weight loss, tiredness, and dizziness – these can be signs of adrenal problems
  • Blurred vision due to glaucoma or cataracts.

Serious allergic reactions happen very rarely. If you have a severe allergic reaction (anaphylaxis) including breathlessness, lip swelling or tongue swelling, call 999 immediately.

Sereflo may not be suitable for everyone. You should tell your prescriber if you:

  • Have an allergy to any of the ingredients in Sereflo
  • Have ever had an allergic reaction to any other medication
  • Have a heart rhythm abnormality
  • Have thyroid disease
  • Have low potassium levels on blood testing
  • Have diabetes
  • Are pregnant, trying to conceive, or breastfeeding – this is because it is important that your asthma is well controlled at this time.

Your prescriber can then advise whether Sereflo is a suitable medication for you.

Occasionally, using a new inhaler can lead to worsening of your symptoms. If you notice shortness of breath, wheeze, or a persistent cough after taking Sereflo inhaler, use your reliever inhaler and contact your doctor straight away.

Some medications can interact with Sereflo. You may be advised that Sereflo will not suit you if you already take:

  • Beta blockers
  • Medications for HIV or AIDS
  • Antifungal medications.

Because Sereflo may not suit everyone, we will complete a Consultation with you including a health questionnaire. This will ensure that the medication will be suitable for you.

A qualified prescriber will review your current medications, including any herbal remedies or supplements, to ensure that Sereflo will not interact with them. 

Once prescribed, Sereflo will be ordered on your behalf via electronic prescription. Sereflo will then be conveniently dispatched from one of our partner pharmacies.

Buy Sereflo

Buying Sereflo Online

Can I buy Sereflo online?

You can safely buy Sereflo online at EU Meds. You will first need to have an online consultation with a pharmacist independent prescriber before your order will be supplied. The online consultation will ensure that Sereflo is the right medication for your medical condition.

Do I need a prescription for Sereflo?

Yes, in order to purchase Sereflo you will need a valid prescription. Please note, all requests for supply of prescription medications are subject to an online clinical consultation and the decision to prescribe will be made by a doctor.

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