The Role of Saxenda in Diabetes and Weight Loss

In this article, we will take a look at the connection between diabetes, obesity, and Saxenda, exploring how this medication, also known as liraglutide, can play a role in managing both conditions. We'll outline the fundamentals of diabetes and obesity, discuss what Saxenda and liraglutide are, and how these medications can aid in weight loss and diabetes management. As well as this, we'll also answer other frequently asked questions about the usage and effectiveness of Saxenda so you are completely informed.

Diabetes Explained

Diabetes is a chronic condition characterised by either insufficient insulin production by the pancreas or ineffective utilisation of the insulin produced by the body, according to the World Health Organisation. Insulin, which is a crucial hormone in the human body, regulates blood glucose levels which are crucial for overall health. This condition can lead to elevated blood sugar levels, potentially causing health complications if it is not managed effectively.

Obesity Explained

Obesity is a chronic health condition characterised by an accumulation of excessive fat in the body that poses potential risks to overall well-being. It's associated with an elevated likelihood of developing type 2 diabetes, heart disease, and certain cancers, according to the World Health Organisation. Obesity can impact bone health, fertility, and the quality of daily activities such as sleep and mobility.

Saxenda Injections Explained

Saxenda, also known as liraglutide, is an injectable prescription medication primarily intended for adults with excess weight and weight-related medical issues or obesity. It is administered via self-injection. Saxenda is typically prescribed to adults with a body mass index (BMI) of 30 or higher, or adults with a BMI of 27 or higher who also have weight-related health conditions. This medication is designed to aid weight loss when it is used alongside a reduced-calorie diet and increased exercise levels.

Liraglutide Explained

Liraglutide is a medication used to treat type 2 diabetes, obesity, and also as a weight loss aid. It belongs to a class of drugs called glucagon-like peptide-1 (GLP-1) receptor agonists. These medications work by mimicking the action of a hormone called GLP-1, which helps regulate blood sugar levels, promotes feelings of fullness, and slows down digestion. Liraglutide can help individuals lose weight by reducing appetite and calorie intake. It is typically administered via injection and is often prescribed alongside lifestyle modifications such as a healthy diet and regular exercise (Day, 2017).

Does Liraglutide lower blood glucose levels?

Yes, liraglutide is known to lower blood glucose levels. As a GLP-1 receptor agonist, it mimics the action of the natural hormone GLP-1, which plays a crucial role in regulating blood sugar levels. Liraglutide works by stimulating the release of insulin from the pancreas, which helps to lower blood glucose levels. It also reduces the production of glucagon, a hormone that raises blood sugar levels (Nuffer, 2019).

Does Liraglutide reduce body weight?

Yes, liraglutide, particularly under the brand name Saxenda, has been approved for weight loss purposes. Another brand of liraglutide called Victoza is primarily indicated for treating type 2 diabetes. Saxenda contributes to weight loss and also offers other cardiovascular benefits. Both Saxenda and Victoza are typically prescribed alongside a healthy balanced diet and increased physical activity to aid in weight management and loss (Anderson, 2023).

How does exercise and diet impact the effectiveness of Liraglutide?

Combining exercise and liraglutide has shown promising results in enhancing healthy weight loss, surpassing the outcomes of either treatment alone (Lundgren et al., 2021). Liraglutide stands out as the only medication currently proven effective against weight regain, making it a preferable choice over other weight-loss medications (Doggrell, 2021). It has also demonstrated an ability to initiate and sustain weight loss in individuals grappling with obesity (Mehta, Marso & Neeland, 2017). These studies outline the significance of incorporating both exercise and diet modifications alongside liraglutide medications to maximise its effectiveness.

Is there a risk of hypoglycemia or weight gain when using Liraglutide?

Liraglutide is generally well tolerated as a long-term weight loss medication. However, like with any medication, there are potential adverse effects to consider. Among the most common side effects include nausea, hypoglycemia, diarrhoea, constipation, vomiting, headache, dyspepsia, fatigue, dizziness, abdominal pain, and increased lipase levels. Hypoglycemia is another term for low blood sugar levels. While hypoglycemia is listed as a common side effect, it's essential to note that liraglutide primarily works to lower blood sugar levels in individuals with diabetes and may not pose a significant risk of hypoglycemia (Mehta, Marso & Neeland, 2017).

Is Liraglutide more effective for weight loss in females compared to males?

In a 2022 study, across all examined groups females consistently experienced greater weight loss from liraglutide compared to males. This suggests that liraglutide may be more effective for weight loss in females than in males. However, individual responses to medications can vary, and it's essential for healthcare providers to consider individual factors when prescribing liraglutide or any other weight-loss medication (Rentzeperi et al, 2022).

Can Liraglutide improve the function of β-cells?

Liraglutide has shown the potential to improve beta-cell function in individuals with newly diagnosed and well-controlled type 2 diabetes. It may reduce postprandial glucose levels without increasing insulin concentration. However, it's important to note that while liraglutide may improve beta-cell function, it may not have a significant impact on glucagon excursions. This suggests that liraglutide could be beneficial in managing type 2 diabetes by enhancing the function of beta cells, which are responsible for producing insulin (Anholm et al, 2019).

Does generic Saxenda (Liraglutide) work?

Currently, you cannot purchase generic Saxenda. If you are looking for a medication with the generic active ingredient that is in Saxenda, liraglutide, to help treat weight loss, then you will need to purchase Saxenda. Saxenda is proven to be highly effective at helping aid weight loss when it is used alongside regular exercise and a healthy, balanced diet.

Can liraglutide cause any adverse effects?

Yes, like many medications, liraglutide can cause adverse effects. Some of the more common side effects associated with liraglutide according to the Mayo Clinic include:

• Bladder pain

• Bloody or cloudy urine

• Chills

• Cough

• Diarrhoea

• Difficult, burning, or painful urination

• Fever

• Frequent urge to urinate

• General feeling of discomfort or illness

• Headache

• Hoarseness

• Joint pain

• Loss of appetite

• Lower back or side pain

• Muscle aches and pains

• Nausea

• Runny nose

• Shivering

• Sore throat

• Sweating

• Trouble sleeping

• Unusual tiredness or weakness

• Vomiting

Is Saxenda available to buy at EU Meds?

Yes, you can purchase Saxenda online from EU Meds by simply selecting the product and completing our online consultation form. If your consultation is approved then you will be provided with a free private prescription that allows you to purchase the medication that you need.

What alternative diabetes medications are available at EU Meds?

At EU Meds we have alternative diabetes medications that are suitable for many different people. We provide patients with Metformin, a medication that helps lower blood sugar levels and improve glycemic control in individuals with diabetes. Metformin is one of the most commonly prescribed diabetes medications and can be purchased online from EU Meds.

What alternative weight loss medications are available at EU Meds?

Ozempic is a brand name for semaglutide, which is another medication in the same class as liraglutide, the active ingredient in Saxenda. Both Ozempic and Saxenda are glucagon-like peptide-1 (GLP-1) receptor agonists, which means they work by mimicking the action of the natural hormone GLP-1 in the body. Ozempic can also be used to help treat type 2 diabetes. You can purchase Ozempic online from EU Meds by completing our free online consultation.

Medically Reviewed by:
Dr. Irfan Siddique MBBS
GMC reference no: 7694522
LinkedIn

Sources

• Saxenda - About Saxenda

• Medicines.org.uk - Saxenda Summary of Product Characteristics

• Drugs.com - Saxenda

• NICE - Liraglutide